Oura Ring Gen 4 sensor data — not clinical measurementsN=1 case study — not validated for clinical decisionsHEV diagnosed Mar 18; interpret findings cautiously in this Day 72 post-ruxolitinib window

Anomaly Detection

ML-powered analysis: Matrix Profile, Isolation Forest, LSTM Autoencoder, SPC, tsfresh+DBSCAN
Generated 2026-05-28 07:29 · Post-HSCT Patient
Anomaly Days
Elevated
14.0
Above 90th percentile
Feb 9 Detection
Detected
2/5
40% method agreement (N=1)
High Severity
Detected
80.0
Score >= 0.7
Moderate
Detected
34.0
Score 0.4-0.7
53% higher mean anomaly score after ruxolitinib (72 days)
Data period: 2026-01-08 to 2026-05-26 (140 days) · Known acute event: 2026-02-09

Validation: February 9 Event

Methods Detected
Low
2/5
Method Agreement (N=1)
Weak
40%

Detection results per method:

Matrix ProfileIsolation ForestLstm AutoencoderSpcTsfresh

The Feb 8-9, 2026 event is a clinically confirmed acute episode (HR spike to 113 bpm mean, RMSSD drop to 5.0 ms, readiness score 29). All anomaly detectors are validated against this event.

Anomaly Timeline

Statistical Process Control (SPC)

LSTM Autoencoder - Training Curve

Top Anomalies (Ensemble Scoring)

#DateEnsemble ScoreRMSSD (ms) HR (bpm)EfficiencyReadinessMethods (score > 0.5)
12026-04-091.22220.284-%-2/5
22026-04-081.2099.111267%502/5
32026-05-261.185-112-%-2/5
42026-02-09 **1.1685.011076%292/5
52026-04-291.11548.98187%822/5
62026-04-281.08140.27372%782/5
72026-05-181.07920.18682%692/5
82026-04-241.07846.58583%802/5
92026-05-211.07325.49888%602/5
102026-04-271.05940.08382%732/5
112026-04-161.03938.98068%842/5
122026-04-051.0379.411169%662/5
132026-05-251.03436.69187%872/5
142026-05-201.03345.18981%812/5
152026-04-061.0296.911481%492/5

** = known acute event. Methods (score > 0.5) is a soft support count and is not the same as strict Feb 9 detection validation above.

Clinical Interpretation

Summary

Five independent anomaly detection algorithms were run retrospectively on 140 days of biometric data from the Oura Ring (Jan-Mar 2026).

Validation Against Known Event

2 of 5 methods detected the acute event on Feb 8-9, 2026. The event ranks as #4 in ensemble anomaly scoring.

This event showed dramatic HRV collapse (RMSSD 5.0 ms), mean heart rate 113.9 bpm during sleep, and readiness score 29/100 with recovery index 4/100 - consistent with acute autonomic destabilization.

Top 5 Anomalies

  1. 2026-04-09
  2. 2026-04-08
  3. 2026-05-26
  4. 2026-02-09
  5. 2026-04-29

Clinical Relevance

Baseline RMSSD ~10 ms is critically low (parasympathetic deficiency threshold (Kleiger 1987 / Bigger 1992): 15 ms, population median: 49 ms, typical post-HSCT: 25-40 ms). Any further decline represents severe autonomic stress. Mean nightly heart rate >89 bpm meets IST criteria (>90 bpm at rest).

Limitations

Method Summary

MethodRuntimeFeb 9 DetectedDetails
Matrix Profile0sNostumpy not installed
Isolation Forest0.4sYes14 anomalies / 140 days
Lstm Autoencoder0sNotorch not installed
Spc0.01sYesShewhart + CUSUM + EWMA
Tsfresh0sNotsfresh not installed
All metrics derived from Oura Ring Gen 4 consumer wearable data. Not clinical-grade measurements.
Single-patient case study (N=1). Not validated for clinical decision-making. Not a medical device.
Data: January 08 – May 26, 2026 · Post-intervention: 72 days (ruxolitinib, March 16)
Open source under MIT License · © 2026 The Educational Equality Institute · GitHub
Updated daily at 06:15 CET · Last generated: 2026-05-28 07:29
This project is not affiliated with, endorsed by, or sponsored by Oura Health Oy. Oura® is a registered trademark of Oura Health Oy.